Year : 2014  |  Volume : 7  |  Issue : 3  |  Page : 269-273

Euglycemic control: does it affect the incidence of chest infection in ICU patients?

Department of Anesthesiology, Intensive Care, and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Hesham M Elazzazi
Department of Anesthesiology, Intensive Care, and Pain Management, Faculty of Medicine, Ain Shams University, 11646 Cairo
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1687-7934.139541

Rights and Permissions

Background Acute hyperglycemia in ICU patients is associated with increased risk for nosocomial infections by raising plasma levels of proinflammatory cytokines, stimulating muscle-protein degradation, and inhibiting protein synthesis, which could contribute to muscle wasting. Euglycemic control with insulin reduced septicemia and the need for prolonged antibiotic therapy, prevented nosocomial infection, accelerated resolution of inflammation, and reduced muscle catabolism . Patients and methods A total of 200 patients of both sex, diabetic or nondiabetic, aged 20-70 years admitted to ICU of Ain Shams University Hospitals for more than 2 days who gave written and informed consent were enrolled in the study. Age, sex, clinical assessment for chest infection, C-reactive protein, chest radiograph, random blood sugar, HbA1C, and serum potassium were recorded at the time of ICU admission. Patients were divided into two groups. Group I was the euglycemic control group (n = 100 patients) in which blood sugar was kept between 100 and 120 mg/dl using regular insulin infusion and group II (n = 100 patients) received the standard care using an intravenous insulin infusion titrated to maintain blood glucose between 120 and 180 mg/dl. Blood sugar was measured every 1 h in both groups; indicator of chest infection (clinical signs, C-reactive protein, and chest radiography) was performed daily. Results Regarding all demographic data (age and sex), there were no statistically significant differences between the studied groups (P = 0.744 and 0.730, respectively). Regarding duration of ICU stay, there was a significantly higher rate of ICU stay for more than 7 days among patients of group II (P < 0.001). Comparing the incidence of chest infection in group I and group II, there was low incidence of chest infection in four patients (4%) of group I , whereas 18 patients (18%) of group II (22 of 200 patients) showed chest infection (P 0.003). Conclusion Euglycemic control reduces the incidence of chest infection in ICU patients.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded163    
    Comments [Add]    

Recommend this journal