ORIGINAL ARTICLE
Year : 2015  |  Volume : 8  |  Issue : 2  |  Page : 236-243

Comparison of dexmedetomidine and fentanyl for attenuation of the hemodynamic response to laryngoscopy and tracheal intubation


Department of Anesthesia, Jawaharlal Nehru Medical College, Wardha, India

Correspondence Address:
Vaibhav Jain
Department of Anesthesia, Jawaharlal Nehru Medical College, Wardha - 442 001
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1687-7934.156699

Rights and Permissions

Background The pressor response, which is part of a huge spectrum of stress responses, results from the increase in sympathetic and sympathoadrenal activity. This study was conducted to compare the efficacy of dexmedetomidine and fentanyl for attenuation of largyngoscopic pressor response. Patients and methods Sixty patients of ASA I and II were randomly divided into two groups. Group D patients received an injection of dexmedetomidine at a dose of 1 μg/kg, whereas group F patients received an injection of fentanyl at a dose of 2 μg/kg preoperatively over 10 min before induction of anesthesia with an injection of thiopentone and vecuronium. After laryngoscopy, anesthesia was maintained with isoflurane (0.6% v/v)+N 2 O (50%)+O 2 (50%). Intraoperatively, heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure (MBP), SpO 2 , and ECG were recorded at the following intervals: at baseline, after drug administration (at 2, 5, and 8 min), before induction, after induction, and after laryngoscopy. Results Dexmedetomidine significantly attenuated the sympathetic response to laryngoscopy and intubation in terms of heart rate, systolic blood pressure, and diastolic blood pressure compared with fentanyl. The total dose of thiopentone for induction of general anesthesia was significantly less in the dexmedetomidine group as compared with the fentanyl group. Incidence of bradycardia and hypotension was higher in patients of the dexmedetomidine group when compared with the fentanyl group. Conclusion An intravenous infusion of dexmedetomidine at 1 μg/kg administered 10 min before laryngoscopy and endotracheal intubation can be recommended over fentanyl at 2 μg/kg to attenuate the sympathetic response to laryngoscopy and endotracheal intubation with minimal side effects.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3544    
    Printed83    
    Emailed0    
    PDF Downloaded494    
    Comments [Add]    
    Cited by others 2    

Recommend this journal