ORIGINAL ARTICLE
Year : 2016  |  Volume : 9  |  Issue : 1  |  Page : 18-22

Prevention of reperfusion tachyarrhythmia after CABG: magnesium versus lidocaine


Cardiothoracic Anesthesia Unit, Department of Anesthesia & SIC, Mansoura Faculty of Medicine, Mansoura, Egypt

Correspondence Address:
Magdy M Atallah
Cardiothoracic Anesthesia Unit, Department of Anesthesia & SIC, Mansoura Faculty of Medicine, Mansoura
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1687-7934.178874

Rights and Permissions

Background Reperfusion tachyarrhythmia after aortic cross-clamp (ACC) release is one of the most commonly encountered complications after coronary artery bypass grafting (CABG) surgery, and its control may save these patients. Materials and methods Ninety patients who had undergone CABG surgery were enrolled in this study. Patients were assigned randomly to three groups (30 patients each). The lidocaine group (LIDO) group received lidocaine (2 mg/kg) in 100 ml isotonic saline, the magnesium group (MAGN) group received magnesium (30 mg/kg) diluted in 100 ml of an isotonic saline 0.9% solution, and the control group received 100 ml normal saline by a pump circuit 3-5 min before ACC release. Anesthetic management, weaning protocol from cardiopulmonary bypass, was standardized. All the patients were monitored after the release of ACC and electrical rhythms (including ventricular fibrillation and supraventricular tachyarrhythmia) were recorded. Results Incidences of postrelease of ACC and ventricular fibrillation were lower in the lidocaine and magnesium groups compared with the control group [7 (23%), 4 (13%) vs. 11 (36%)] (P = 0.042). Also, the incidence of an atrioventricular block postrelease ACC was higher in the lidocaine group compared with the magnesium and control groups [7 (23%) vs. 2 (6%) and 3 (10%), respectively] (P = 0.039). The need for a temporary pace maker was higher in the lidocaine group compared with the magnesium and control groups [7 (23%) vs. 2 (6%) and 1 (3%), respectively] (P = 0.044). Also, the total duration of ICU stay was shorter in the magnesium group compared with the lidocaine and control groups. Conclusion The administration of lidocaine and magnesium sulfate before the release of ACC reduced the incidence of ventricular fibrillation. The administration of magnesium shortened the ICU stay in adult patients undergoing CABG surgery by cardiopulmonary bypass. However, the administration of Lidocaine was associated with more transient atrioventricular block.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed866    
    Printed7    
    Emailed0    
    PDF Downloaded166    
    Comments [Add]    
    Cited by others 1    

Recommend this journal