Ain-Shams Journal of Anaesthesiology

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 10  |  Issue : 1  |  Page : 173--176

Perioperative terlipressin infusion in living donor liver transplantation: effects on sodium and water balance


Tarek S Shabana, Sherif G Anis, Fady A Abdelmalek 
 Department of Anesthesia, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Tarek S Shabana
Department of Anesthesia, Faculty of Medicine, Ain Shams University, Cairo
Egypt

Background Although terlipressin is being used perioperatively in recipients of liver transplantation to improve splanchnic hemodynamics and postoperative renal functions, its associated antidiuretic effect has not been specifically investigated in this group of patients. The aim of this study is to assess the effect of terlipressin infusion started intraoperatively and continued for 48 h postoperatively in recipients of living donor liver transplantation on serum sodium and water/sodium excretion. Materials and methods Thirty patients with end-stage liver disease and portal hypertension scheduled for living donor liver transplantation were randomized into two groups including 15 patients each. Group 1 (control): patients did not receive terlipressin. Group 2: terlipressin was administered as an infusion at a rate of 2 µg/kg/h continued for 48 h after postoperative ICU admission. Comparisons were performed between both groups in terms of serum sodium, urine sodium, urine osmolarity, and the urine : sodium osmolarity ratio. Results There were no significant changes between the control group and the terlipressin group in serum sodium, urine sodium, urine osmolarity, and the urine : sodium osmolarity ratio. Conclusion Terlipressin infusion started intraoperatively at a rate of 2 µg/kg/h and continued for 48 h postoperatively in recipients of living donor liver transplantation did not result in significant changes in serum sodium and sodium/water excretion.


How to cite this article:
Shabana TS, Anis SG, Abdelmalek FA. Perioperative terlipressin infusion in living donor liver transplantation: effects on sodium and water balance.Ain-Shams J Anaesthesiol 2017;10:173-176


How to cite this URL:
Shabana TS, Anis SG, Abdelmalek FA. Perioperative terlipressin infusion in living donor liver transplantation: effects on sodium and water balance. Ain-Shams J Anaesthesiol [serial online] 2017 [cited 2021 Apr 21 ];10:173-176
Available from: http://www.asja.eg.net/article.asp?issn=1687-7934;year=2017;volume=10;issue=1;spage=173;epage=176;aulast=Shabana;type=0